Sickle Cell Disease And Its Effects - 1879 Words

Sickle Cell Disease Sickle cell disease affects approximately 100,000 Americans and millions across the globe (Sobota, 2015). The three most common types of sickle cell disease are Hb SS (sickle cell anemia), Hb SC, and Hb S beta thalassemia, with Hb SS being the most common type (Harris, 2001). Sickle cell disease occurs in individuals who inherit the mutated hemoglobin gene, from one or both of their parents. The mutated hemoglobin, known as Hb S, crystalizes and join together â€Å"into many small cords, which form chains that look like twisted wires† (Harris, 2001, p. 20). Stretched to contain the Hb S crystals, the red blood cells take on spike and sickle shapes; this is how the name for the disease came about (Harris, 2001). Deformed, the sickled cells have a hard time moving through the blood stream and can eventually pile up in the blood vessels, having life-threatening consequences. Although oxygen can reverse the sickling process in cells, turning Hb S back into a li quid, after a few sicklings the red blood cells’ membrane is permanently damaged and the cell will remain sickled. The History of Sickle Cell Disease American physician James Herrick was the first to describe sickle cell disease. In 1910, Herrick observed â€Å"peculiar elongated and sickle-shaped red blood corpuscles† in the blood film of a West Indian student suffering from leg ulcers, shortness of breath, and jaundice (Chakravorty Williams, 2015, p. 48). In 1922, three more similar case were observed andShow MoreRelatedThe Effects Of Sickle Cell Disease On Daily Life2454 Words   |  10 Pages Effects of Sickle Cell Disease on Daily Life Alyssa Bodnar NSG 401-Pediatric Nursing University of North Carolina Wilmington Abstract Sickle Cell disease is a genetic disorder found primarily in minority descents throughout the world. Because of recent accomplishments in medical research, those diagnosed with Sickle Cell disease are able to lead much more fulfilling lives instead of lives filled with excruciating pain. Though crises caused by the disease process may be unavoidableRead MorePharmacogenomics Of Sickle Cell Disease1444 Words   |  6 PagesPharmacogenomics of Sickle Cell Disease Abstract Hydroxyurea is a treatment therapy that is currently used to treat sickle cell disease. There are a total of 23 single nuclear polymorphisms (SNPs) that are involved with sickle cell disease. When hydroxyurea is given at an optimal maximum dose, it will act on the BCL11A gene and increase the fetal hemoglobin concentrations. There are a total of 5 SNPs that are associated with the BCL11A gene. Some parameters that were observed are differences inRead MoreCoping Strategies And Techniques Among Sickle Cell Disease1195 Words   |  5 PagesOjong Bate â€Å"Coping strategies and techniques amongst people living with sickle cell Disease† Introduction: Sickle cell disease (SCD) is one of the many chronic health conditions yet to be well understood by health care professionals; hematologists included. It is an inherited genetic condition characterized by sickled shaped red blood cells, which alter their oxygen carring capacity. Sickle cell disease is passed from parents to offspring and it is characterized by numerous complications suchRead MoreSickle Cell Anemia Essay1530 Words   |  7 PagesSickle cell anemia is an inherited disease in which the body is unable to produce normal hemoglobin, an iron-containing protein. Sickle cell anemia is a disease in which the body is unable to produce normal hemoglobin, an iron-containing protein. Abnormal hemoglobin can change cells that can become stuck in narrow blood vessels, blocking oxygen from reaching organs and tissues. Tissue that does not get a normal blood flow eventually becomes damaged. This is what causes the problems of sickle cellRead MoreSickle Of Sickle Cell Disease706 Words   |  3 PagesSickle Cell Disease Sickle Cell Disease or also widely known as Sickle Cell Anemia is a genetic mutation caused in red blood cells destroys its own cells within and reshaping the cell wall resembling crescent or sickle shape; getting its name of the sickle cell disease. These sickled shaped cells attempt to perform its normal function of circulating oxygenated and deoxygenated RBC and gets lodged in small vessels causing vaso-occlusion. Where vaso-occlusive take effect, rest of the body is not receivingRead More Discovering Sicke Cell Anemia Essay1320 Words   |  6 PagesDiscovering Sicke Cell Anemia The topic that I am learning about is Sickle Cell Anemia, a hereditary disease which affects red blood cells. Throughout this research paper, I will discuss what exactly it is, how it is caused, any known treatments or cures, and many other facts that are important in this disease. Sickle Cell Anemia is a health problem throughout the world. More than 250,000 babies are born worldwide with this inherited blood cell disorder (http://www.medaccess.com/h_child/sickle/sca_01.htm)Read MoreA Study On Sickle Cell Disease1560 Words   |  7 Pages Sickle-cell disease majorly affects the hemoglobin that is present in our blood. The job of hemoglobin is to help transport oxygen and carbon dioxide to and from the cells throughout our body. Hemoglobin is present specifically in our red blood cells. Each red blood cell contains two hundred and eighty million hemoglobin molecules. Red blood cells normal shape is a biconcave shape because of the lack of many organelles and a nucleus. The shape is so important to a red blood cells functioning thatRead MoreThe Probability of Inheriting a Disease Is Not Random1816 Words   |  7 Pagesprobability of inheriting a disease is not random. There are several factors that determine the chances on inheriting a disease such as race, gender, genetics, etc. A person of Caucasian decent is more likely to develop cystic fibrosis, an Asian person has a higher chance of inheriting Ka wasaki disease and there is a very high rate of Sickle Cell Anemia among people of African lineage. Sickle Cell disease is inherited and it affects the anatomy of the red blood cells, resulting in a sickle shape which thenRead More Sickle Cell Anemia Essay1282 Words   |  6 PagesThe sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell have red blood cells that have mostly hemoglobins, Sometimes these red blood cells become sickle-shaped or crescent shaped and have trouble going through small blood vessels. When sickle-shaped cells block small blood vessels, less blood can get to that part of the body. Tissue that does not get a normal blood flow eventually becomes damaged.This is what causes the problems of sickle cellRead MoreSickle Cell Anemia ( Sca )1516 Words   |  7 PagesSickle cell anemia (SCA) is an inherited blood disease which causes normal, round, healthy red blood cells to transform into sickle-shaped cells. Normal red blood cells are flexible and can easily pass through capillaries to bring oxygen to different parts of the body. However, sickle cells are fragile, and can easily die, leading to anemia (red blood cell deficiency). SCA can also cause blood vessel occlusion (blockage of blood vessels), tissue infarctions (death due to lack of oxygen), bone, joint